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Article

Genetic priming of a proinflammatory profile predicts low IQ in octogenarians.

Neurobiology of aging - 1 May 2009

Krabbe K S, Mortensen E L, Avlund K, Pilegaard H, Christiansen L, Pedersen A N, Schroll M, Jørgensen T, Pedersen B K, Bruunsgaard H

Abstract excerpt

The purpose of the study was to test the hypothesis that single nucleotide polymorphisms (SNPs) within interleukin (IL)-18, TNF-alpha, IL-6 and IL-10 gene promoter regions are risk factors for cognitive decline in healthy octogenarians, and to isolate the strongest inflammatory biomarkers of cognitive function in the peripheral blood. The Wechsler Adult Intelligence Scale was administered to 112 individuals at...

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PMID: 17913303
DOI: 10.1016/j.neurobiolaging.2007.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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