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Article

Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2010

Dato Serena, Krabbe Karen S, Thinggaard Mikael, Pedersen Bente K, Christensen Kaare, Bruunsgaard Helle, Christiansen Lene

Abstract excerpt

Systemic low-grade inflammation is consistently associated with functional status, cognitive functioning, multimorbidity, and survival in oldest olds. If inflammation is either a cause or a consequence of age-related pathology, genetic determinants of late-life survival can reside in cytokine genes polymorphisms, regulating inflammatory responses. The aim of this study was to test associations between commonly...

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PMID: 20083555
DOI: 10.1093/gerona/glp210
PMCID: PMC2822285

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