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Article

Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 2007

Bossù Paola, Ciaramella Antonio, Moro Maria Luisa, Bellincampi Lorenza, Bernardini Sergio, Federici Giorgio, Trequattrini Alberto, Macciardi Fabio, Spoletini Ilaria, Di Iulio Fulvia, Caltagirone Carlo, Spalletta Gianfranco

Abstract excerpt

BACKGROUND AND AIM: Inflammation has been extensively implicated in the pathogenesis of Alzheimer's disease (AD). Although there is evidence of a key role for cytokines in neuroinflammation processes, so far the proinflammatory cytokine interleukin (IL)-18 has not been associated with AD. The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Case-Control Studies
Cognition Disorders
Female
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Polymorphism, Genetic

Prognosis

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 17299019
DOI: 10.1136/jnnp.2006.103242
PMCID: PMC2117732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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