Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Oct 2007

Spalletta Gianfranco, Bernardini Sergio, Bellincampi Lorenza, Federici Giorgio, Trequattrini Alberto, Ciappi Fabrizio, Bria Pietro, Caltagirone Carlo, Bossù Paola

Abstract excerpt

OBJECTIVE: Oxidative stress has been suggested as a contributor of Alzheimer disease (AD) neurodegeneration, particularly in those patients with late-onset AD (LOAD). Therefore, the authors studied the effect of glutathione S-transferase (GST) P1-M1-T1 gene polymorphisms and their interactions with the apolipoprotein E (ApoE) epsilon4 allelic variant on the three-year longitudinal course of AD. METHODS: Global...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activities of Daily Living
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

Share to Neuropsychological Tests

Share to Psychiatric Status Rating Scales

Share to Regression Analysis

Source

Identifiers

PMID: 17911365
DOI: 10.1097/JGP.0b013e3180547076

Genes

GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease.PMID 17911365Read ↗

Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients.Semantic proximity Read ↗

Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer's disease.Semantic proximity Read ↗

Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

Association of glutathione S-transferases M1, P1 and T1 variations and risk of late-onset Alzheimer's disease.Semantic proximity Read ↗

A preliminary study on the influence of glutathione S transferase T1 (GSTT1) as a risk factor for late onset Alzheimer's disease in North Indian population.Semantic proximity Read ↗

MTHFR Gene Mutations: A Potential Marker of Late-Onset Alzheimer's Disease?Semantic proximity Read ↗

Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease.Semantic proximity Read ↗

Gene dose of the epsilon 4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease.Semantic proximity Read ↗

The Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Late-Onset Alzheimer's disease: Further Evidence in an Italian Multicenter Study.Semantic proximity Read ↗

Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease.Semantic proximity Read ↗

PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.