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Article

MTHFR Gene Mutations: A Potential Marker of Late-Onset Alzheimer's Disease?

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Román Gustavo C

Abstract excerpt

Recent epigenome-wide association studies have confirmed the importance of epigenetic effects mediated by DNA methylation in late-onset Alzheimer's disease (LOAD). Metabolic folate pathways and methyl donor reactions facilitated by B-group vitamins may be critical in the pathogenesis of LOAD. Methylenetetrahydrofolate reductase (MTHFR) gene mutations were studied in consecutive Alzheimer's Disease & Memory Clinic...

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Source

Identifiers

PMID: 26401555
DOI: 10.3233/JAD-150304

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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