Article
Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele.
Clinical chemistry - 1 Jun 2005
Bernardini Sergio, Bellincampi Lorenza, Ballerini Sabrina, Federici Giorgio, Iori Roberta, Trequattrini Alberto, Ciappi Fabrizio, Baldinetti Francesca, Bossù Paola, Caltagirone Carlo, Spalletta Gianfranco
Abstract excerpt
BACKGROUND: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathione transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE genotypes to investigate their role as susceptibility...
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