Article
Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2006
Fernández Del Pozo Valentina, Alvarez Alvarez Maite, Fernández Martínez Manuel, Galdós Alcelay Luis, Gómez Busto Fernando, Peña Jose A, Alfonso-Sánchez Miguel A, Zarranz Imirizaldu Juan José, de Pancorbo Marian M
Abstract excerpt
BACKGROUND: Late-onset Alzheimer's disease (LOAD) is associated with changes in certain proteins, such as ApoE and Cyp46A1, of the elimination route for cerebral cholesterol. The main lipoprotein involved in its transport is ApoE whose Epsilon4 allele is the least efficient. However, the presence or absence of this allele does not determine the development of LOAD, which implies the existence of other...
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