Article
Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E epsilon4 allele.
Clinical chemistry and laboratory medicine - 1 Jan 2008
Pinhel Marcela A S, Nakazone Marcelo A, Cação João C, Piteri Rafael C O, Dantas Raoni T, Godoy Moacir F, Godoy Maria R P, Tognola Waldir A, Conforti-Froes Nívea D T, Souza Dorotéia
Abstract excerpt
BACKGROUND: Several factors participate in the pathogenesis of Alzheimer's disease (AD), including free radicals, which when out of balance with their antioxidant capacity contribute to the oxidative stress process and neuronal death. The glutathione S-transferase (GST) polymorphisms are associated with the organism detoxification capacity and can help with the identification of sub-groups that present...
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