Article
The Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Late-Onset Alzheimer's disease: Further Evidence in an Italian Multicenter Study.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Stoccoro Andrea, Tannorella Pierpaola, Salluzzo Maria Grazia, Ferri Raffaele, Romano Corrado, Nacmias Benedetta, Siciliano Gabriele, Migliore Lucia, Coppedè Fabio
Abstract excerpt
BACKGROUND: A functional polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, namely C677T (rs1801133), results in increased Hcy levels and has been associated with risk of late-onset Alzheimer's disease (LOAD). Many investigators reported association between rs1801133 and LOAD risk in Asian populations and in carriers of the apolipoprotein E (APOE) ɛ4 allele, but recent meta-analyses suggest a...
Topics
- Age of Onset
- Aged
- Alzheimer Disease
- Apolipoproteins E
- Case-Control Studies