Article
Gene dose of the epsilon 4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease.
Annals of neurology - 1 May 1995
Frisoni G B, Govoni S, Geroldi C, Bianchetti A, Calabresi L, Franceschini G, Trabucchi M
Abstract excerpt
A strong association has been described in cross-sectional studies between the epsilon 4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD). This study addresses the relationship between disease progression and the epsilon 4 allele in 62 sporadic LOAD (onset at age 70 and over) patients. Disease progression was estimated retrospectively with the Mini-Mental State Examination (MMSE) amounting...
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