Article
Gene dose of the epsilon 4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease.
Annals of neurology - 1 May 1995
Frisoni G B, Govoni S, Geroldi C, Bianchetti A, Calabresi L, Franceschini G, Trabucchi M
Abstract excerpt
A strong association has been described in cross-sectional studies between the epsilon 4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD). This study addresses the relationship between disease progression and the epsilon 4 allele in 62 sporadic LOAD (onset at age 70 and over) patients. Disease progression was estimated retrospectively with the Mini-Mental State Examination (MMSE) amounting...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Analysis of Variance
- Apolipoproteins E
- Disease Progression
- Female
- Gene Dosage
- Humans