Cell cycle reentry and cell proliferation as candidates for the seizure predispositions in the hippocampus of EL mouse brain.

Abstract excerpt

We have recently found that there was DNA fragmentation without cell loss in the hippocampus in EL mice, an epileptic mutant. Neurotrophic factors are also expressed at high levels during the early developmental stages. In the present study, we used EL mice to examine how altered cyclin and the corresponding cyclin dependent kinase (CDK) family are related to cell proliferation during development and during...

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