Article
The critical role of cyclin D2 in adult neurogenesis.
The Journal of cell biology - 25 Oct 2004
Kowalczyk Anna, Filipkowski Robert K, Rylski Marcin, Wilczynski Grzegorz M, Konopacki Filip A, Jaworski Jacek, Ciemerych Maria A, Sicinski Piotr, Kaczmarek Leszek
Abstract excerpt
Adult neurogenesis (i.e., proliferation and differentiation of neuronal precursors in the adult brain) is responsible for adding new neurons in the dentate gyrus of the hippocampus and in the olfactory bulb. We describe herein that adult mice mutated in the cell cycle regulatory gene Ccnd2, encoding cyclin D2, lack newly born neurons in both of these brain structures. In contrast, genetic ablation of cyclin D1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.