Article
Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain.
Brain research - 7 Sept 2006
Golestaneh Nady, Tang Yi, Katuri Varalakshmi, Jogunoori Wilma, Mishra Lopa, Mishra Bibhuti
Abstract excerpt
The mammalian forebrain subependyma contains neural stem cells and other proliferating progenitor cells. Recent studies have shown the importance of TGF-beta family members and their adaptor proteins in the inhibition of proliferation in the nervous system. Previously, we have demonstrated that TGF-beta induces phosphorylation and association of ELF (embryonic liver fodrin) with Smad3 and Smad4 resulting in...
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