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Article

E2F1 works as a cell cycle suppressor in mature neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Nov 2007

Wang Li, Wang Rong, Herrup Karl

Abstract excerpt

Neurons are highly differentiated cells that normally never enter a cell cycle; if they do, the result is usually death, not division. For example, cerebellar granule neurons in staggerer and lurcher mutant mice initiate a cell cycle-like process just before they die. E2F1 is a transcription factor that promotes cell cycle progression. Because E2F1 is also involved in apoptosis, we bred double mutants (E2f1-/-;...

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Identifiers

PMID: 18003834
DOI: 10.1523/JNEUROSCI.3681-07.2007
PMCID: PMC6673327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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