Article
The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse.
The American journal of pathology - 1 Mar 2009
Lee Hyoung-gon, Casadesus Gemma, Nunomura Akihiko, Zhu Xiongwei, Castellani Rudy J, Richardson Sandy L, Perry George, Felsher Dean W, Petersen Robert B, Smith Mark A
Abstract excerpt
Many different proteins associated with the cell cycle, including cyclins, cyclin-dependent kinases, and proto-oncogenes such as c-MYC (MYC), are increased in degenerating neurons. Consequently, an ectopic activation of the cell cycle machinery in neurons has emerged as a potential pathogenic mechanism of neuronal dysfunction and death in many neurodegenerative diseases, including Alzheimer's disease. However,...
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