Article
Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice.
Journal of neuroscience research - 1 Nov 2002
Yuasa Shigeki, Nakajima Mitsunari, Aizawa Hidenori, Sahara Naruhiko, Koizumi Ken-Ichi, Sakai Tsuyoshi, Usami Mihoko, Kobayashi Shin-Ichiro, Kuroyanagi Hidehito, Mori Hiroshi, Koseki Haruhiko, Shirasawa Takuji
Abstract excerpt
Recent studies have implicated presenilin-1 (PS-1) in the processing of the amyloid precursor protein and Notch-1. We show that PS-1 has biological effects on differentiation and cell cycle control of neuronal precursor cells in vivo using PS-1-deficient mice. The expression of Class III beta-tubulin was upregulated throughout the neocortical primordia of PS-1-deficient E14 embryos, especially on the ventricular...
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