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Article

Cell‐context specific role of the E2F/Rb pathway in development and disease

30 Sept 2009

Abstract excerpt

Development of the central nervous system (CNS) requires the generation of neuronal and glial cell subtypes in appropriate numbers, and this demands the careful coordination of cell-cycle exit, survival, and differentiation. The E2F/Rb pathway is critical for cell-cycle regulation and also modulates survival and differentiation of distinct cell types in the developing and adult CNS. In this review, we first...

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PMID: 19795505
DOI: 10.1002/glia.20933

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