Article
p27kip1 Is Required for Functionally Relevant Adult Hippocampal Neurogenesis in Mice.
Stem cells (Dayton, Ohio) - 1 Mar 2017
Hörster Henrik, Garthe Alexander, Walker Tara L, Ichwan Muhammad, Steiner Barbara, Khan Muhammad Amir, Lie Dieter Chichung, Nicola Zeina, Ramirez-Rodriguez Gerardo, Kempermann Gerd
Abstract excerpt
We asked whether cell-cycle associated protein p27kip1 might be involved in the transition of precursor cells to postmitotic maturation in adult hippocampal neurogenesis. p27kip1 was expressed throughout the dentate gyrus with a strong nuclear expression in early postmitotic, calretinin-positive neurons and neuronally determined progenitor cells (type-3 and some type-2b), lower or absent expression in radial...
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