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Article

A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum.

The American journal of pathology - 1 Aug 1999

Migheli A, Piva R, Casolino S, Atzori C, Dlouhy S R, Ghetti B

Abstract excerpt

A missense mutation in the gene coding for the G-protein-activated inwardly rectifying potassium (GIRK) channel, GIRK2, is responsible for apoptosis in the external germinal layer (EGL) of the cerebellum and a nonapoptotic death of midbrain dopaminergic neurons in the weaver (wv) mouse. Failure of axonogenesis and migration are considered to be the primary consequences of GIRK2 channel malfunction in the...

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Identifiers

PMID: 10433930
DOI: 10.1016/S0002-9440(10)65133-4
PMCID: PMC1866868

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PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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