Article
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
Genes, chromosomes & cancer - 1 Jan 2008
Paulsson Kajsa, Horvat Andrea, Strömbeck Bodil, Nilsson Fredrik, Heldrup Jesper, Behrendtz Mikael, Forestier Erik, Andersson Anna, Fioretos Thoas, Johansson Bertil
Abstract excerpt
Although it has been suggested that mutations of the FLT3, NRAS, KRAS, and PTPN11 genes are particularly frequent in high hyperdiploid (>50 chromosomes) pediatric acute lymphoblastic leukemias (ALLs), this has as yet not been confirmed in a large patient cohort. Furthermore, it is unknown whether mutations of these genes coexist in hyperdiploid cases. We performed mutation analyses of FLT3, NRAS, KRAS, and PTPN11...
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