Article
The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.
Nature genetics - 1 Jun 2015
Paulsson Kajsa, Lilljebjörn Henrik, Biloglav Andrea, Olsson Linda, Rissler Marianne, Castor Anders, Barbany Gisela, Fogelstrand Linda, Nordgren Ann, Sjögren Helene, Fioretos Thoas, Johansson Bertil
Abstract excerpt
High hyperdiploid (51-67 chromosomes) acute lymphoblastic leukemia (ALL) is one of the most common childhood malignancies, comprising 30% of all pediatric B cell-precursor ALL. Its characteristic genetic feature is the nonrandom gain of chromosomes X, 4, 6, 10, 14, 17, 18 and 21, with individual trisomies or tetrasomies being seen in over 75% of cases, but the pathogenesis remains poorly understood. We performed...
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