Article
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations
Haematologica - 1 Dec 2021
Antić Željko, Yu Jiangyan, Van Reijmersdal Simon V, Van Dijk Anke, Dekker Linde, Segerink Wouter H, Sonneveld Edwin, Fiocco Marta, Pieters Rob, Hoogerbrugge Peter M, Van Leeuwen Frank N, Van Kessel Ad Geurts, Waanders Esme, Kuiper Roland P
Abstract excerpt
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring lesions in relapse-associated genes. However, the clinical relevance of these subclonal alterations remains unclear. We assessed the clinical relevance and prognostic value of subclonal alterations in the relapse-associated genes IKZF1, CREBBP, KRAS, NRAS,...
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