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Article

Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia.

Pediatric blood & cancer - 1 Feb 2018

Liang Der-Cherng, Chen Shih-Hsiang, Liu Hsi-Che, Yang Chao-Ping, Yeh Ting-Chi, Jaing Tang-Her, Hung Iou-Jih, Hou Jen-Yin, Lin Tung-Huei, Lin Chun-Hui, Shih Lee-Yung

Abstract excerpt

BACKGROUND: We aimed to investigate the frequencies and the association with genetic/cytogenetic abnormalities as well as prognostic relevance of RAS pathway mutations in Taiwanese children with B-precursor acute lymphoblastic leukemia (ALL), the largest cohort in Asians. PROCEDURE: Between 1995 and 2012, marrow samples at diagnosis from 535 children were studied for NRAS, KRAS, and PTPN11 mutations. The...

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Identifiers

PMID: 28853218
DOI: 10.1002/pbc.26786

Genes

KRAS
NRAS
PTPN11
ETV6
PBX1
RUNX1
TCF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia.PMID 28853218Read ↗

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