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Article

Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil.

Leukemia & lymphoma - 1 Jul 2014

Barbosa Thayana Conceição, Andrade Francianne Gomes, Lopes Bruno Almeida, de Andrade Camilla Fernanda Gomes, Mansur Marcela Braga, Emerenciano Mariana, Pombo-de-Oliveira Maria S

Abstract excerpt

We analyzed mutations in four genes (FLT3, KRAS/NRAS and PTPN11) that might disrupt the RAS/mitogen activated protein kinase (MAPKinase) signaling pathway, to evaluate their prognostic value in children younger than 16 years old with B-cell precursor acute lymphoblastic leukemia (Bcp-ALL). The ov...

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Source

Identifiers

PMID: 24067137
DOI: 10.3109/10428194.2013.847934

Genes

FLT3
PTPN11
NRAS
AFF1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24067137-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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