Article
Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia.
Haematologica - 1 Mar 2022
Kaburagi Taeko, Yamato Genki, Shiba Norio, Yoshida Kenichi, Hara Yusuke, Tabuchi Ken, Shiraishi Yuichi, Ohki Kentaro, Sotomatsu Manabu, Arakawa Hirokazu, Matsuo Hidemasa, Shimada Akira, Taki Tomohiko, Kiyokawa Nobutaka, Tomizawa Daisuke, Horibe Keizo, Miyano Satoru, Taga Takashi, Adachi Souichi, Ogawa Seishi, Hayashi Yasuhide
Abstract excerpt
RAS pathway alterations have been implicated in the pathogenesis of various hematological malignancies. However, their clinical relevance in pediatric acute myeloid leukemia (AML) is not well characterized. We analyzed the frequency, clinical significance, and prognostic relevance of RAS pathway alterations in 328 pediatric patients with de novo AML. RAS pathway alterations were detected in 80 (24.4%) of 328...
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