Article
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.
Oncotarget - 8 Nov 2016
de Smith Adam J, Ojha Juhi, Francis Stephen S, Sanders Erica, Endicott Alyson A, Hansen Helen M, Smirnov Ivan, Termuhlen Amanda M, Walsh Kyle M, Metayer Catherine, Wiemels Joseph L
Abstract excerpt
High hyperdiploidy (HD), the most common cytogenetic subtype of B-cell acute lymphoblastic leukemia (B-ALL), is largely curable but significant treatment-related morbidity warrants investigating the biology and identifying novel drug targets. Targeted deep-sequencing of 538 cancer-relevant genes was performed in 57 HD-ALL patients lacking overt KRAS and NRAS hotspot mutations and lacking common B-ALL deletions to...
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