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Article

SMK-1/PPH-4.1-mediated silencing of the CHK-1 response to DNA damage in early C. elegans embryos.

The Journal of cell biology - 8 Oct 2007

Kim Seung-Hwan, Holway Antonia H, Wolff Suzanne, Dillin Andrew, Michael W Matthew

Abstract excerpt

During early embryogenesis in Caenorhabditis elegans, the ATL-1-CHK-1 (ataxia telangiectasia mutated and Rad3 related-Chk1) checkpoint controls the timing of cell division in the future germ line, or P lineage, of the animal. Activation of the CHK-1 pathway by its canonical stimulus DNA damage is actively suppressed in early embryos so that P lineage cell divisions may occur on schedule. We recently found that...

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Identifiers

PMID: 17908915
DOI: 10.1083/jcb.200705182
PMCID: PMC2064732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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