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Article

Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos.

The Journal of cell biology - 27 Mar 2006

Holway Antonia H, Kim Seung-Hwan, La Volpe Adriana, Michael W Matthew

Abstract excerpt

In most cells, the DNA damage checkpoint delays cell division when replication is stalled by DNA damage. In early Caenorhabditis elegans embryos, however, the checkpoint responds to developmental signals that control the timing of cell division, and checkpoint activation by nondevelopmental inputs disrupts cell cycle timing and causes embryonic lethality. Given this sensitivity to inappropriate checkpoint...

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Identifiers

PMID: 16549501
DOI: 10.1083/jcb.200512136
PMCID: PMC2063758

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