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Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in <i>C. elegans</i>

2020-06-24

Abstract excerpt

During metazoan development, the cell cycle is remodelled to coordinate proliferation with differentiation. Developmental cues cause dramatic changes in the number and timing of replication initiation events, but the mechanisms and physiological importance of such changes are poorly understood. Cyclin-dependent kinase (CDK) is important for regulating S-phase length in many metazoa, and here we show in the nematod...

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Literature Corpus work
5b88729f-0887-50c3-9dd8-a1100ceca383
DOI
10.1101/2020.06.24.168708
Open publication

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Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in <i>C. elegans</i>DOI 10.1101/2020.06.24.168708
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