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Article

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.

PLoS genetics - 1 Dec 2020

Gaggioli Vincent, Kieninger Manuela R, Klucnika Anna, Butler Richard, Zegerman Philip

Abstract excerpt

During metazoan development, the cell cycle is remodelled to coordinate proliferation with differentiation. Developmental cues cause dramatic changes in the number and timing of replication initiation events, but the mechanisms and physiological importance of such changes are poorly understood. Cyclin-dependent kinases (CDKs) are important for regulating S-phase length in many metazoa, and here we show in the...

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PMID: 33320862
DOI: 10.1371/journal.pgen.1008948
PMCID: PMC7771872

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Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.PMID 33320862Read ↗

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