Article

PCH-2 <sup>TRIP13</sup> regulates spindle checkpoint strength

2018-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Spindle checkpoint strength is dictated by three criteria: the number of unattached kinetochores, cell volume and cell fate. We show that the conserved AAA-ATPase, PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an inactive one, controls checkpoint strength in C. elegans . When we manipulate embryos to decrease cell volume, PCH-2 is no longer required fo...

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Literature Corpus work: 93ca2a67-3cec-508b-9830-08106de0b5c2
DOI: 10.1101/389080

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