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Article

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.

Cell - 4 Aug 2000

Hsu J Y, Sun Z W, Li X, Reuben M, Tatchell K, Bishop D K, Grushcow J M, Brame C J, Caldwell J A, Hunt D F, Lin R, Smith M M, Allis C D

Abstract excerpt

Phosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide range of eukaryotes and has been shown to be required for proper chromosome transmission in Tetrahymena. Here we report that Ipl1/aurora kinase and its genetically interacting phosphatase, Glc7/PP1, are responsible for the balance of H3 phosphorylation during mitosis in Saccharomyces cerevisiae and Caenorhabditis elegans. In...

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PMID: 10975519
DOI: 10.1016/s0092-8674(00)00034-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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