Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.

Archives of general psychiatry - 1 Oct 2006

Van Den Bogaert Ann, Sleegers Kristel, De Zutter Sonia, Heyrman Lien, Norrback Karl-Fredrik, Adolfsson Rolf, Van Broeckhoven Christine, Del-Favero Jurgen

Abstract excerpt

CONTEXT: Tryptophan hydroxylase is the rate-limiting enzyme in the serotonin (5-HT) biosynthetic pathway responsible for the regulation of serotonin levels. Tryptophan hydroxylase 2 (TPH2) was found to be solely expressed in the brain and therefore considered an important susceptibility gene in psychiatric disorders. OBJECTIVE: To determine the role of the brain-specific TPH2 gene in unipolar (UP) disorder and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder

Share to Follow-Up Studies

Share to Serotonin

Share to Sweden

Share to Tryptophan Hydroxylase

Share to White People

Source

Identifiers

PMID: 17015812
DOI: 10.1001/archpsyc.63.10.1103

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.PMID 17015812Read ↗

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.Semantic proximity Read ↗

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects.Semantic proximity Read ↗

Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts.Semantic proximity Read ↗

Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.