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Article

Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2008

Miura Shin-ichiro, Kiya Yoshihiro, Kanazawa Takanori, Imaizumi Satoshi, Fujino Masahiro, Matsuo Yoshino, Karnik Sadashiva S, Saku Keijiro

Abstract excerpt

Although the sartan family of angiotensin II type 1 (AT(1)) receptor blockers (ARBs), which includes valsartan, olmesartan, and losartan, have a common pharmacophore structure, their effectiveness in therapy differs. Although their efficacy may be related to their binding strength, this notion has changed with a better understanding of the molecular mechanism. Therefore, we hypothesized that each ARB differs with...

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Identifiers

PMID: 17901125
DOI: 10.1210/me.2007-0312
PMCID: PMC2725753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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