Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers against stretch-induced AT(1) receptor activation.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Oct 2009

Qin Yingjie, Yasuda Noritaka, Akazawa Hiroshi, Ito Kaoru, Kudo Yoko, Liao Chien-Hui, Yamamoto Rie, Miura Shin-Ichiro, Saku Keijiro, Komuro Issei

Abstract excerpt

Type 1 angiotensin II (AT(1)) receptor has a critical role in the development of load-induced cardiac hypertrophy. Recently, we showed that mechanical stretching of cells activates the AT(1) receptor without the involvement of angiotensin II (AngII) and that this AngII-independent activation is i...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin II Type 1 Receptor Blockers
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imidazoles

Share to Losartan

Share to Proto-Oncogene Proteins c-fos

Share to Rats, Wistar

Share to Receptor, Angiotensin, Type 1

Share to Tetrazoles

Source

Identifiers

PMID: 19662020
DOI: 10.1038/hr.2009.117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19662020-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers against stretch-induced AT(1) receptor activation.PMID 19662020Read ↗

Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state.Semantic proximity Read ↗

Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan SyndromeSemantic proximity Read ↗

Cross-inhibition of angiotensin AT1 receptors supports the concept of receptor oligomerization.Semantic proximity Read ↗

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.Semantic proximity Read ↗

AT1 receptor blocker-insensitive mutant AT1A angiotensin receptors reveal the presence of G protein-independent signaling in C9 cells.Semantic proximity Read ↗

Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes.Semantic proximity Read ↗

Constitutive activity in the angiotensin II type 1 receptor: discovery and applications.Semantic proximity Read ↗

The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.Semantic proximity Read ↗

Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy.Semantic proximity Read ↗

"Network leaning" as a mechanism of insurmountable antagonism of the angiotensin II type 1 receptor by non-peptide antagonists.Semantic proximity Read ↗

Internalization of constitutively active N111G MUTANT of AT1 receptor induced by angiotensin II-receptor antagonists candesartan, losartan, and telmisartan: comparison with valsartan.Semantic proximity Read ↗

Dual agonistic and antagonistic property of nonpeptide angiotensin AT1 ligands: susceptibility to receptor mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.