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Article

A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists.

The Journal of biological chemistry - 12 Jul 2002

Joubert Lara, Claeysen Sylvie, Sebben Michèle, Bessis Anne-Sophie, Clark Robin D, Martin Renee S, Bockaert Joël, Dumuis Aline

Abstract excerpt

Activation of G protein-coupled receptors is thought to involve disruption of intramolecular interactions that stabilize their inactive conformation. Such disruptions are induced by agonists or by constitutively active mutations. In the present study, novel potent inverse agonists are described t...

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Identifiers

PMID: 11976337
DOI: 10.1074/jbc.M202539200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11976337-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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