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Article

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.

The Journal of biological chemistry - 4 Dec 2015

Zhang Haitao, Unal Hamiyet, Desnoyer Russell, Han Gye Won, Patel Nilkanth, Katritch Vsevolod, Karnik Sadashiva S, Cherezov Vadim, Stevens Raymond C

Abstract excerpt

Angiotensin II type 1 receptor (AT1R) is the primary blood pressure regulator. AT1R blockers (ARBs) have been widely used in clinical settings as anti-hypertensive drugs and share a similar chemical scaffold, although even minor variations can lead to distinct therapeutic efficacies toward cardiovascular etiologies. The structural basis for AT1R modulation by different peptide and non-peptide ligands has remained...

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Identifiers

PMID: 26420482
DOI: 10.1074/jbc.M115.689000
PMCID: PMC4705918

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