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Article

In silico prediction of ARB resistance: A first step in creating personalized ARB therapy.

PLoS computational biology - 1 Nov 2020

Anderson Shane D, Tabassum Asna, Yeon Jae Kyung, Sharma Garima, Santos Priscilla, Soong Tik Hang, Thu Yin Win, Nies Isaac, Kurita Tomomi, Chandler Andrew, Alsamarah Abdelaziz, Kanassatega Rhye-Samuel, Luo Yun L, Botello-Smith Wesley M, Andresen Bradley T

Abstract excerpt

Angiotensin II type 1 receptor (AT1R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT1R gene. The AT1R coding sequence contains over 100 nsSNPs; therefore, this study embarked on determining which nsSNPs may abrogate the binding of selective ARBs. The crystal structure of...

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Identifiers

PMID: 33237899
DOI: 10.1371/journal.pcbi.1007719
PMCID: PMC7725353

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