Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate.

Neoplasia (New York, N.Y.) - 1 Sept 2007

Matarasso Noa, Bar-Shira Anat, Rozovski Uri, Rosner Serena, Orr-Urtreger Avi

Abstract excerpt

Overexpression of the centrosome-associated serine/threonine kinase Aurora Kinase A (AURKA) has been demonstrated in both advanced prostate cancer and high-grade prostatic intraepithelial neoplasia lesions. The single-nucleotide polymorphism T91A (Phe31Ile) has been implicated in AURKA overexpression and has been suggested as a low-penetrance susceptibility allele in multiple human cancers, including prostate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androgens
Share to Aurora Kinase A
Share to Aurora Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitosis

Share to Neoplasms, Hormone-Dependent

Share to Prostate

Share to Prostatic Neoplasms

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 17898866
DOI: 10.1593/neo.07322
PMCID: PMC1993855

Genes

AURKA
NKTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate.PMID 17898866Read ↗

Common genetic polymorphisms of AURKA and prostate cancer risk.Semantic proximity Read ↗

Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.Semantic proximity Read ↗

Post-transcriptional control drives Aurora kinase A expression in human cancersSemantic proximity Read ↗

The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of IkappaBalpha.Semantic proximity Read ↗

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.Semantic proximity Read ↗

Pathogenic mutation hotspots in protein kinase domain structure.Semantic proximity Read ↗

Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population.Semantic proximity Read ↗

AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study.Semantic proximity Read ↗

A single nucleotide polymorphism in codon F31I and V57I of the AURKA gene in invasive ductal breast carcinoma in Middle East.Semantic proximity Read ↗

Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk.Semantic proximity Read ↗

Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States).Semantic proximity Read ↗

Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.