Pathogenic mutation hotspots in protein kinase domain structure.

Abstract excerpt

Control of eukaryotic cellular function is heavily reliant on the phosphorylation of proteins at specific amino acid residues, such as serine, threonine, tyrosine, and histidine. Protein kinases that are responsible for this process comprise one of the largest families of evolutionarily related proteins. Dysregulation of protein kinase signaling pathways is a frequent cause of a large variety of human diseases...

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• Aurora Kinase A
• Models, Molecular
• Mutation
• Phosphorylation
• Protein Kinases