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Article

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.

International journal of cancer - 15 Jan 2006

Hienonen Tuija, Salovaara Reijo, Mecklin Jukka-Pekka, Järvinen Heikki, Karhu Auli, Aaltonen Lauri A

Abstract excerpt

In a previous genome-wide effort we identified a novel candidate colorectal cancer (CRC) susceptibility locus by allelotyping tumors from familial and sporadic CRC patients. Familial cases harbored amplifications significantly more frequently in 20q13, indicating the presence of a putative oncoge...

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Source

Identifiers

PMID: 16049965
DOI: 10.1002/ijc.21344

Genes

AURKA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16049965-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.PMID 16049965Read ↗

Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal CancerSemantic proximity Read ↗

Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.Semantic proximity Read ↗

Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.Semantic proximity Read ↗

Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate.Semantic proximity Read ↗

AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study.Semantic proximity Read ↗

Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.Semantic proximity Read ↗

Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population.Semantic proximity Read ↗

Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations.Semantic proximity Read ↗

Aurora kinases A and B and familial breast cancer risk.Semantic proximity Read ↗

The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of IkappaBalpha.Semantic proximity Read ↗

Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression.Semantic proximity Read ↗

Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk.Semantic proximity Read ↗

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