Article
Common genetic polymorphisms of AURKA and prostate cancer risk.
Cancer causes & control : CCC - 1 Mar 2009
Feik Elisabeth, Baierl Andreas, Madersbacher Stephan, Schatzl Georg, Maj-Hes Agnes, Berges Richard, Micksche Michael, Gsur Andrea
Abstract excerpt
PURPOSE: AURKA is a centrosome-associated serine/threonine kinase involved in mitotic chromosomal segregation. The AURKA gene is located on chromosome 20q13, also known as HPC20 prostate cancer susceptibility locus. Therefore, we investigated in this Caucasian case-control study two single nucleotide polymorphisms (SNPs) of the AURKA gene, rs8173 located in the 3'-untranslated region (G1891C) and rs2273535 in...
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