Article
AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2007
Couch Fergus J, Sinilnikova Olga, Vierkant Robert A, Pankratz V Shane, Fredericksen Zachary S, Stoppa-Lyonnet Dominique, Coupier Isabelle, Hughes David, Hardouin Agnès, Berthet Pascaline, Peock Susan, Cook Margaret, Baynes Caroline, Hodgson Shirley, Morrison Patrick J, Porteous Mary E, Jakubowska Anna, Lubinski Jan, Gronwald Jacek, Spurdle Amanda B, Schmutzler Rita, Versmold Beatrix, Engel Christoph, Meindl Alfons, Sutter Christian, Horst Jurgen, Schaefer Dieter, Offit Kenneth, Kirchhoff Tomas, Andrulis Irene L, Ilyushik Eduard, Glendon Gordon, Devilee Peter, Vreeswijk Maaike P G, Vasen Hans F A, Borg Ake, Backenhorn Katja, Struewing Jeffery P, Greene Mark H, Neuhausen Susan L, Rebbeck Timothy R, Nathanson Katherine, Domchek Susan, Wagner Theresa, Garber Judy E, Szabo Csilla, Zikan Michal, Foretova Lenka, Olson Janet E, Sellers Thomas A, Lindor Noralane, Nevanlinna Heli, Tommiska Johanna, Aittomaki Kristiina, Hamann Ute, Rashid Muhammad U, Torres Diana, Simard Jacques, Durocher Francine, Guenard Frederic, Lynch Henry T, Isaacs Claudine, Weitzel Jeffrey, Olopade Olufunmilayo I, Narod Steven, Daly Mary B, Godwin Andrew K, Tomlinson Gail, Easton Douglas F, Chenevix-Trench Georgia, Antoniou Antonis C
Abstract excerpt
The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA...
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