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Article

Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States).

Cancer causes & control : CCC - 1 Feb 2006

Cox David G, Hankinson Susan E, Hunter David J

Abstract excerpt

AURKA is an important protein in the regulation of G2 to M transition during mitosis. Due to this regulatory function, it has been hypothesized to be a potential cancer susceptibility gene. Two non-synonymous polymorphisms (F31I and V57I) have been associated with breast cancer risk in prior studies. We sought to confirm these findings in a large case control study nested within a prospective cohort, the Nurses'...

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Source

Identifiers

PMID: 16411056
DOI: 10.1007/s10552-005-0429-9

Genes

AURKA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States).PMID 16411056Read ↗

Two nonsynonymous polymorphisms (F31I and V57I) of the STK15 gene and breast cancer risk: a meta-analysis based on 5966 cases and 7609 controls.Semantic proximity Read ↗

Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK.Semantic proximity Read ↗

Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians.Semantic proximity Read ↗

Two functional coding single nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk.Semantic proximity Read ↗

Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.Semantic proximity Read ↗

STK15 F31I polymorphism is associated with increased uterine cancer risk: a pilot study.Semantic proximity Read ↗

A single nucleotide polymorphism in codon F31I and V57I of the AURKA gene in invasive ductal breast carcinoma in Middle East.Semantic proximity Read ↗

STK15 polymorphism and breast cancer risk in a population-based study.Semantic proximity Read ↗

Association between the STK15 polymorphisms and risk of cancer: a meta-analysis.Semantic proximity Read ↗

Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects.Semantic proximity Read ↗

AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study.Semantic proximity Read ↗

Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population.Semantic proximity Read ↗

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