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Article

Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.

Carcinogenesis - 1 Nov 2004

Sun Tong, Miao Xiaoping, Wang Jinwei, Tan Wen, Zhou Yifeng, Yu Chunyuan, Lin Dongxin

Abstract excerpt

Aurora-A/BTAK/STK15, involved in regulating centrosomes and chromosome segregation, is overexpressed in human breast carcinoma and other cancers. The Phe31-->Ile polymorphism in Aurora A alters the kinase function, with the Ile31 variant being preferentially amplified and associated with degree of aneuploidy in human tumors. We have previously shown that the Phe31Ile polymorphism is associated with the occurrence...

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PMID: 15271856
DOI: 10.1093/carcin/bgh244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.PMID 15271856Read ↗

Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK.Semantic proximity Read ↗

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Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States).Semantic proximity Read ↗

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Two nonsynonymous polymorphisms (F31I and V57I) of the STK15 gene and breast cancer risk: a meta-analysis based on 5966 cases and 7609 controls.Semantic proximity Read ↗

Aurora kinases A and B and familial breast cancer risk.Semantic proximity Read ↗

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Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population.Semantic proximity Read ↗

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