Article

Post-transcriptional control drives Aurora kinase A expression in human cancers

2024-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Aurora kinase A (AURKA) is a major regulator of the cell cycle. A prominent association exists between high expression of AURKA and cancer, and impairment of AURKA levels can trigger its oncogenic activity. In order to explore the contribution of post-transcriptional regulation to AURKA expression in different cancers, we carried out a meta-analysis of -omics data of 18 cancer types from The Can...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c33b809b-f607-504d-96a8-f7a273ed8f75
DOI: 10.1101/2024.02.22.581549

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Post-transcriptional control drives Aurora kinase A expression in human cancersDOI 10.1101/2024.02.22.581549Read

Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious DiseasesSemantic proximity Read

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapySemantic proximity Read

Overexpression of Aurora Kinase B Is Correlated with Diagnosis and Poor Prognosis in Hepatocellular CarcinomaSemantic proximity Read

A pan-cancer interrogation of intronic polyadenylation and its association with cancer characteristicsSemantic proximity Read

Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinomaSemantic proximity Read

An analysis of AURKB's prognostic and immunological roles across various cancers.Semantic proximity Read

AURKA promotes renal cell carcinoma progression via regulation of CCNB1 transcriptionSemantic proximity Read

Biology of Aurora A kinase: Implications in cancer manifestation and therapySemantic proximity Read

Aurora kinase A in gastrointestinal cancers: time to targetSemantic proximity Read

Aurka orchestrates colorectal cancer progression through dual regulation of tumor proliferation and immune microenvironmentSemantic proximity Read

Functional Significance of Aurora Kinases–p53 Protein Family Interactions in CancerSemantic proximity Read

Identification and Validation of Aurora Kinase A (AURKA) Involved in the Progression and Imatinib Resistance of Advanced Gastrointestinal Stromal TumorsSemantic proximity Read