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Article

Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma.

International journal of medical sciences - 1 Jan 2018

Wang Bin, Hsu Chin-Jung, Chou Chia-Hsuan, Lee Hsiang-Lin, Chiang Whei-Ling, Su Chen-Ming, Tsai Hsiao-Chi, Yang Shun-Fa, Tang Chih-Hsin

Abstract excerpt

Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as...

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Share to Asian People
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Share to Biomarkers, Tumor
Share to Carcinoma, Hepatocellular
Share to Case-Control Studies
Share to Gene Frequency
Share to Liver Neoplasms
Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 29333101
DOI: 10.7150/ijms.22513
PMCID: PMC5765730

Genes

AURKA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma.PMID 29333101Read ↗

Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma.Semantic proximity Read ↗

Overexpression of Aurora Kinase B Is Correlated with Diagnosis and Poor Prognosis in Hepatocellular CarcinomaSemantic proximity Read ↗

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Impact of Aurora Kinase A Polymorphism and Epithelial Growth Factor Receptor Mutations on the Clinicopathological Characteristics of Lung Adenocarcinoma.Semantic proximity Read ↗

Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.Semantic proximity Read ↗

Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population.Semantic proximity Read ↗

Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal CancerSemantic proximity Read ↗

The AURKA gene rs2273535 polymorphism contributes to breast carcinoma risk - meta-analysis of eleven studies.Semantic proximity Read ↗

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapySemantic proximity Read ↗

AURKB targets DHX9 to promote hepatocellular carcinoma progression via PI3K/AKT/mTOR pathwaySemantic proximity Read ↗

Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility.Semantic proximity Read ↗

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