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Identification of a synonymous polymorphism within the cytochrome P4502C9 gene that interferes with identification of the CYP2C9*2 allele.

Therapeutic drug monitoring - 1 Oct 2007

Womack Edward P, Reynolds Kristen K, Valdes Roland, Linder Mark W

Abstract excerpt

Cytochrome P450 2C9 (CYP4502C9) genotyping is useful in dosage adjustments for several critical drug therapies, including warfarin. Potential interference compromising these genotyping results could lead to inappropriate dose adjustments that may result in adverse drug reactions. During routine clinical CYP4502C9 genotyping using multiplex allele-specific primer extension, an ambiguous result was obtained for...

Topics

Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C9
DNA
DNA Primers
Gene Frequency
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17898651
DOI: 10.1097/FTD.0b013e3181354b9b

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