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Article

Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese.

Pharmacogenetics - 1 Feb 1995

Wang S L, Huang J, Lai M D, Tsai J J

Abstract excerpt

Cytochrome P450 (CYP) 2C9 catalyses the metabolism of a wide range of drugs. Previous studies have shown the differences in the amino acid composition among CYP2C9 variants at Cys144/Arg, Tyr358/Cys, Leu359/Ile, and Gly417/Asp. PCR-endonuclease digestion methods have been developed to detect these four possible polymorphisms. The T416-->C mutation in exon 3 of CYP2C9 (Cys144-->Arg) creates an Ava II site. In the...

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PMID: 7773301
DOI: 10.1097/00008571-199502000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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