Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese.

doi:10.1097/00008571-199502000-00004

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Article

Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese.

Pharmacogenetics - 1 Feb 1995

Wang S L, Huang J, Lai M D, Tsai J J

Abstract excerpt

Cytochrome P450 (CYP) 2C9 catalyses the metabolism of a wide range of drugs. Previous studies have shown the differences in the amino acid composition among CYP2C9 variants at Cys144/Arg, Tyr358/Cys, Leu359/Ile, and Gly417/Asp. PCR-endonuclease digestion methods have been developed to detect these four possible polymorphisms. The T416-->C mutation in exon 3 of CYP2C9 (Cys144-->Arg) creates an Ava II site. In the...

Topics

Alleles
Aryl Hydrocarbon Hydroxylases
Asian People
Base Sequence
China
Cytochrome P-450 CYP2C9
Cytochrome P-450 Enzyme System
DNA Primers
Exons
Genetic Variation
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Introns

Molecular Sequence Data

Point Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7773301
DOI: 10.1097/00008571-199502000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7773301-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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