A simple method for the detection of CYP2C9 polymorphisms: nested allele-specific multiplex polymerase chain reaction.

doi:10.1016/s0009-8981(03)00319-x

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Article

A simple method for the detection of CYP2C9 polymorphisms: nested allele-specific multiplex polymerase chain reaction.

Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2003

Zainuddin Z, Teh L K, Suhaimi A W M, Salleh M Z, Ismail R

Abstract excerpt

BACKGROUND: Cytochrome P4502C9 (CYP2C9), a principle drug-metabolizing enzyme is polymorphic in humans and is responsible for important pharmacokinetic and pharmacodynamic variations of CYP2C9 substrates. We developed an allele-specific multiplex polymerase chain reaction (PCR) method for the detection of common CYP2C9 alleles. METHOD: Genomic DNA was extracted from blood obtained from 40 unrelated healthy...

Topics

Alleles
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C9
DNA
DNA Primers
Electrophoresis, Agar Gel
Genotype
Humans
Magnesium Chloride
Polymerase Chain Reaction
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 14500040
DOI: 10.1016/s0009-8981(03)00319-x

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